The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2025
Filed:
Dec. 17, 2019
The Broad Institute, Inc., Cambridge, MA (US);
John G. Doench, Cambridge, MA (US);
Ruth Hanna, Cambridge, MA (US);
THE BROAD INSTITUTE, INC., Cambridge, MA (US);
Abstract
The present invention generally relates to systems, methods and compositions related to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof. Provided herein are engineered Cpf1 polynucleotides that can direct the activity of a CRISPR protein to multiple targets using a single crRNA. The guide sequences can target a sequence in a eukaryotic cell, for example, an animal or a plant cell. The animal cell can be a human or a nonhuman cell. Additionally, the present invention relates to methods for developing or designing CRISPR-Cas system-based therapy or therapeutics.