Company Filing History:
1 out of 4,770 
1 out of 1 
5 out of 833,002 Years Active: 1989-2011
Title: Innovations by John F Hartmann
Introduction
John F Hartmann is a notable inventor based in Princeton Junction, NJ (US). He holds a total of 7 patents that reflect his contributions to the field of medical technology and diagnostics. His work primarily focuses on innovative solutions for cancer diagnosis and treatment.
Latest Patents
Hartmann's latest patents include groundbreaking advancements in cancer cell diagnosis through the targeted delivery of nanodevices. One of his significant inventions involves macromolecular contrast agents for magnetic resonance imaging (MRI). These agents utilize biomolecules and their modified derivatives to form stable complexes with paramagnetic ions, thereby enhancing the molecular relaxivity of carriers. He describes the synthesis of biomolecular-based nanodevices designed for the targeted delivery of MRI contrast agents. Notably, nanoparticles (NP) are constructed by self-assembling chitosan (CHIT) as a polycation and poly-gamma glutamic acids (PGA) as a polyanion. These nanoparticles are capable of Gd-ion uptake, forming particles with suitable molecular relaxivity. Additionally, folic acid (FA) is linked to the nanoparticles to create NP-FA bioconjugates, which can be utilized for targeted in vitro delivery to human cancer cell lines. Another patent focuses on therapeutic derivatives of diphosphonates, where compounds are prepared by reacting a 2,2-bis-(disubstituted-phosphoryl)-ethylsulfanyl-acetic acid compound with a pharmaceutically active chemical entity or non-pharmaceutical entities such as pesticides and fungicides.
Career Highlights
Throughout his career, Hartmann has worked with prominent companies, including Merck & Co., Inc. His experience in the pharmaceutical industry has significantly influenced his innovative approaches to medical technology.
Collaborations
Hartmann has collaborated with notable professionals in his field, including Dan A Farcasiu and Pal Herczegh. These collaborations have likely contributed to the development and refinement of his patented technologies.
Conclusion
John F Hartmann's contributions to medical technology through his patents demonstrate his commitment to advancing cancer diagnostics and treatment. His innovative work continues to impact the field significantly.