The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2011
Filed:
Dec. 08, 2008
Janos Borbely, Debrecen, HU;
Magdolna Bodnar, Hajouboszormeny, HU;
John F Hartmann, Princeton Junction, NJ (US);
Istvan Hajdu, Tiszacsege, HU;
Jozsef Kollar, Debrecen, HU;
Gyorgy Vamosi, Debrecen, HU;
Janos Borbely, Debrecen, HU;
Magdolna Bodnar, Hajouboszormeny, HU;
John F Hartmann, Princeton Junction, NJ (US);
Istvan Hajdu, Tiszacsege, HU;
Jozsef Kollar, Debrecen, HU;
Gyorgy Vamosi, Debrecen, HU;
Other;
Abstract
Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line.