John Doran

Title: John Doran: Innovator in Rho-Kinase Research

Introduction

John Doran is a notable inventor based in Medford, MA (US). He has made significant contributions to the field of biochemistry, particularly in the study of Rho-kinase I. His work has implications for understanding protein interactions and developing therapeutic compounds.

Latest Patents

John Doran holds a patent for the "Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof." This invention relates to human Rho-kinase I (ROCK I) and its binding pockets. The patent provides a computer comprising a data storage medium encoded with the structure coordinates of these binding pockets. It also outlines methods for using these coordinates to solve the structure of homologous proteins or protein complexes. Furthermore, the invention includes methods for screening and designing compounds that bind to ROCK I protein or its homologues. The patent also discusses crystallizable compositions and crystals that include the ROCK I kinase domain and its complexes with inhibitors.

Career Highlights

John Doran is currently associated with Vertex Pharmaceuticals, Inc., where he continues to advance his research in the field. His work has been instrumental in enhancing the understanding of Rho-kinase I and its potential therapeutic applications.

Collaborations

Throughout his career, John has collaborated with notable colleagues, including Marc Jacobs and Koto Hayakawa. These collaborations have contributed to the advancement of research in the biochemistry domain.

Conclusion

John Doran's innovative work in Rho-kinase research exemplifies the impact of scientific inquiry on therapeutic development. His contributions continue to shape the understanding of protein interactions and potential treatments.