The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2010
Filed:
Jun. 28, 2006
Marc Jacobs, Boston, MA (US);
Koto Hayakawa, Edmonton, CA;
Mark Fleming, Cambridge, MA (US);
John Doran, Medford, MA (US);
Craig Marhefka, Rockville, MD (US);
Marc Jacobs, Boston, MA (US);
Koto Hayakawa, Edmonton, CA;
Mark Fleming, Cambridge, MA (US);
John Doran, Medford, MA (US);
Craig Marhefka, Rockville, MD (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain.