Succasunna, NJ, United States of America

John Charles Tomesch

USPTO Granted Patents = 24 (Patent Applications = 1)

CIPO Patents = 1

EPO Patents = 5 (Patent Applications = 4)

Average Co-Inventor Count = 3.4

ph-index = 13

Forward Citations = 869(Granted Patents)

Location History:

New York, NY (US) (2014 - 2016)
Succasunna, NJ (US) (1982 - 2022)

Company Filing History:

21 out of 172

Intra-cellular Therapies, Inc.

Years Active: 1982-2024

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24 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 12139490 - Process for preparing 1-(4-fluorophenyl)-4-((6bR, 10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one (2024-11-12),

2. 11407751 - Hydrochloric acid salt of (6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxaline (2022-08-09),

3. RE48825 - 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid salt crystal forms (2021-11-22),

4. 11066407 - Preparation of certain substituted 1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines and pharmaceutically acceptable salts thereof (2021-07-20),

5. 10597395 - Preparation of certain substituted 1-(4-fluorophenyl)-4-(2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-YL)butan-1-ones and pharmaceutically acceptable salts thereof (2020-03-24),

6. 10464938 - Pharmaceutical compositions comprising ((6bR,10aS)-1-(4-fluorophenyl)-4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one or pharmaceutically acceptable salts thereof (2019-11-05),

7. 10221176 - Preparation of certain substituted [((6bR,10aS)-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxalines and pharmaceutically acceptable salts thereof (2019-03-05),

8. 9944648 - Organic compounds (2018-04-17),

9. 9751883 - Preparation of certain [((6BR,10AS)-2,3,6B,7,8,9,10, 10A-octahydro-1H-pyrido[3',4′:4,5]pyrrolo [1,2,3-de]quinoxalines and pharmaceutically acceptable salts thereof (2017-09-05),

10. 9708294 - Organic compounds (2017-07-18),

11. 9586960 - 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de] quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid salt crystal forms (2017-03-07),

12. 9469625 - Organic compounds (2016-10-18),

13. 9452160 - Compounds and methods of prophylaxis and treatment regarding nicotinic receptor antagonists (2016-09-27),

14. 9371324 - Substituted pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders (2016-06-21),

15. 9315504 - Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3',4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof (2016-04-19),

Title: Innovations and Contributions of John Charles Tomesch

Introduction: John Charles Tomesch, a prolific inventor based in Succasunna, New Jersey, has made significant contributions to the field of pharmaceuticals and chemical processes. With an impressive portfolio of 24 patents, Tomesch's work focuses on the development of substituted heterocycle fused gamma-carbolines and other related compounds. His innovative approach has paved the way for advancements in therapeutic applications.

Latest Patents: Among his recent patents, Tomesch has developed a method for preparing 1-(4-fluorophenyl)-4-((6bR, 10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one. This invention provides crucial methods for synthesizing substituted heterocycle fused gamma-carbolines, along with intermediates useful in their production. Another significant patent includes the hydrochloric acid salt of (6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4′:4,5]pyrrolo[1,2,3-de]quinoxaline, which also explores innovative methods for creating these valuable compounds.

Career Highlights: Throughout his career, John Tomesch has collaborated with notable organizations such as Intra-Cellular Therapies, Inc. and Sandoz Pharmaceutical Corporation. His experience within these companies has allowed him to refine his expertise in pharmacology and design of chemical processes, leading to the successful patenting of his inventions.

Collaborations: Tomesch has worked alongside esteemed coworkers like Lawrence P. Wennogle and Qiang Zhang. These collaborative efforts have likely contributed to the robustness of his innovations and the development of impactful pharmaceutical solutions.

Conclusion: John Charles Tomesch stands out as a dedicated inventor with a wealth of knowledge and experience in the realm of chemical processes and pharmaceutical development. His numerous patents reflect his commitment to advancing medical science and delivering innovative solutions. As his career continues to evolve, the impact of his work promises to contribute significantly to future advancements in the industry.

This text is generated by artificial intelligence and may not be accurate.