Location History:
- Lyme, CT (US) (1976 - 1978)
- Groton, CT (US) (1979)
Company Filing History:
Years Active: 1976-1979
Title: The Innovations of John B Routien: Antibiotic Advancements from Lyme, CT
Introduction
John B Routien is a prominent inventor based in Lyme, Connecticut, known for his significant contributions to the field of antibiotic research. With an impressive portfolio of 14 patents, Routien has been at the forefront of developing innovative solutions to combat bacterial and fungal infections. His research not only enhances antibiotic effectiveness but also provides growth-promoting benefits in livestock.
Latest Patents
Among his most notable inventions are two groundbreaking patents focused on antibiotics derived from specific Actinoplanes species. The first patent describes a mixture of antibiotics produced by Actinoplanes auranticolor ATCC 31011. This strain, when subjected to submerged aerobic fermentation under controlled conditions, yields a combination of macrocyclic lactones and depsipeptides, each exhibiting significant antibiotic activity. Notably, the crude antibiotic mixture and combinations of pure compounds showcase remarkable synergistic effects. These antibiotics are effective as growth promotants in chicks and swine, as well as in treating swine dysentery. Furthermore, another strain, Actinoplanes azureus ATCC 31157, produces a mixture of heptaene antibiotics with antifungal properties.
Routien's second patent introduces a new polycyclic ether antibiotic, characterized by its anticoccidial, antimicrobial, and growth-promoting properties. The patent outlines methods for its production through fermentation, recovery, and purification, further emphasizing his innovative approach to antibiotic development.
Career Highlights
John B Routien's professional journey has been significantly tied to the Pfizer Corporation, where he has utilized his expertise to advance antibiotic research. His work has been pivotal in expanding the understanding of antibiotic mixtures and their applications in both medical and agricultural contexts.
Collaborations
Throughout his career, Routien has collaborated with esteemed colleagues such as Walter D Celmer and Walter P Cullen. These professional partnerships have fostered an environment of innovation and discovery, contributing to the development of effective antibiotic solutions.
Conclusion
In summary, John B Routien’s contributions to antibiotic research mark him as a vital inventor in the field. His significant patents and collaborative efforts at Pfizer Corporation continue to influence the landscape of medical and agricultural sciences. With a commitment to innovation, Routien exemplifies how targeted research can lead to breakthroughs that benefit both health and agriculture.