Pfizer Corporation

John B Routien

Walter P Cullen

Walter D Celmer

Charles E Moppett

Junsuke Tone

Riichiro Shibakawa

John R Oscarson

Mark T Jefferson

Frank C Sciavolino

Paul C Watts

Charles E Moppet

A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery. This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.

Mixture of antibiotics produced by a species of actinoplanes

A new polycyclic ether antibiotic with anticoccidial, antimicrobial and growth promotant properties, its production by fermentation and methods for its recovery and purification are described.

Polycyclic ether antibiotic

A new sulfur-containing polypeptide antibiotic produced by two strains of Streptosporangium under submerged fermentation conditions is useful for the treatment of microbial infections and in improving feed utilization efficiency in ruminants.

Polypeptide antibiotic produced by a new subspecies of streptosporangium

A new polycyclic ether antibiotic produced by three strains of a new species of Dactylosporangium under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.

Polycyclic ether antibiotic produced by new species of dactylosporangium

A new species of Micromonospora, designated Micromonospora lacustris sp. nov. Routien, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of at least 13 antibiotics. Two of these antibiotics are rifamycin S and rifamycin SV. Two other members of the antibiotic mixture are the 3-methylthio derivatives of rifamycin S and rifamycin SV.

Mixture of antibiotics produced by new species of micromonospora

A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.

Polycyclic ether antibiotic for combating insects

A new species of Micromonospora, designated Micromonospora saitamica sp. nov. Routien, when subjected to submerged aerobic fermentation, produces at least four antibiotics. One of these is previously reported rubradirin produced by Streptomyces achromogenes var. rubradiris NRRL 3061.

Two new species of Streptosporangium, designated Streptosporangium koreanum Routien sp. nov. and Streptosporangium cinnabarinum Routien sp. nov., when subjected to submerged aerobic fermentation, produce the same two new antibiotics. Methods for the recovery and purification of these antibiotics, co-produced with minor antibiotics, are described and some of their antimicrobial properties are outlined.

Mixture of antibiotics produced by new species of streptosporangium

A new species of Pseudonocardia, designated Pseudonocardia fastidiosa sp. nov. Routein, when subjected to submerged aerobic fermentation, produces two new antibiotics. Methods for the recovery and purification of these antibiotics are described and some of their antimicrobial properties are outlined.

Antibiotics produced by species of pseudonocardia

A new species of Micromonospora, designated Micromonospora lacustris sp. nov. Routien, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of at least thirteen antibiotics. Two of these antibiotics are rifamycin S and rifamycin SV. Two other members of the antibiotic mixture are the 3-methylthio derivatives of rifamycin S and rifamycin SV.

Disclosed is a new antibiotic, Compound 41,012, which is produced by the submerged aerobic fermentation of a new species of Actinoplanes designated Actinoplanes nipponensis sp. nov. Routien, ATCC 31145. Methods for the recovery and purification of Compound 41,012 are also described as are some of its antimicrobial properties.

Antibiotic Compound 41,012

Antibiotic Compound 37,504 is produced by the submerged aerobic fermentation under controlled conditions of a new species of Micromonospora designated Micromonospora viridifaciens sp. nov. Routien, ATCC 31146.

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Lyme, CT, United States of America

John B Routien