Johannes Hubertus Wieringa

Title: Innovations of Johannes Hubertus Wieringa

Introduction

Johannes Hubertus Wieringa is a notable inventor based in Oss, Netherlands. He has made significant contributions to the field of pharmaceuticals, particularly in the development of compounds with antidepressant activity. With a total of 3 patents, Wieringa's work has had a meaningful impact on the treatment of serotonin-related diseases.

Latest Patents

Wieringa's latest patents include a method for the preparation of enantiomerically pure mirtazapine. This invention provides a method that involves a step of ring closure of a compound, resulting in mirtazapine with enantiomeric excess. The process is characterized by treatment with an acid, either in the absence of a solvent or in combination with an organic solvent. Another significant patent involves compounds of azetidine and pyrrolidin, which are designed to treat or prevent serotonin-related diseases. These compounds have a specific formula that includes various substituents and may comprise heteroatoms.

Career Highlights

Throughout his career, Wieringa has worked with prominent companies such as Akzo Nobel N.V. and N.V. Organon. His experience in these organizations has contributed to his expertise in pharmaceutical innovations and development.

Collaborations

Wieringa has collaborated with notable individuals in his field, including Dirk Leysen and Christophorus Louis Eduard Broekkamp. These collaborations have likely enhanced his research and development efforts.

Conclusion

Johannes Hubertus Wieringa's contributions to pharmaceutical innovations, particularly in the area of antidepressant compounds, highlight his role as a significant inventor. His patents reflect a commitment to advancing medical science and improving treatment options for patients.