The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2011
Filed:
Jul. 05, 2004
Johannes Hubertus Wieringa, Oss, NL;
Adrianus Antonius Martinus Van DE Ven, Oss, NL;
Gerardus Johannes Kemperman, Oss, NL;
Johannes Hubertus Wieringa, Oss, NL;
Adrianus Antonius Martinus Van De Ven, Oss, NL;
Gerardus Johannes Kemperman, Oss, NL;
N.V. Organon, Oss, NL;
Abstract
The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirlazapine with enantiomeric excess is formed by the ring closure of the compound of formula (II) with enantiomeric excess by treatment with a suitable acid in the absence of a solvent or a suitable combination of an acid and an organic solvent.