Johannes Gregorius Dauwerse

Title: Johannes Gregorius Dauwerse: Innovator in NOTCH3 Protein Modulation

Introduction

Johannes Gregorius Dauwerse is a notable inventor based in Delft, Netherlands. He has made significant contributions to the field of medical research, particularly in the modulation of NOTCH3 protein expression. With a total of 2 patents, his work focuses on innovative methods for treating CADASIL, a genetic disorder.

Latest Patents

Dauwerse's latest patents include "Means and methods for modulating NOTCH3 protein expression and/or the coding region of NOTCH3; compositions and use thereof in the treatment of CADASIL." This invention provides methods for modulating NOTCH3 expression and the protein coding domain. One aspect of the invention involves a method for reducing elevated levels of NOTCH3 protein in a NOTCH3 expressing cell. This is achieved by providing the cell with an anti-sense oligonucleotide specific for NOTCH3 mRNA or pre-mRNA, thereby decreasing the production of NOTCH3 protein or altering the protein coding region in the mRNA.

Career Highlights

Dauwerse is affiliated with the Academic Hospital Leiden, known as LUMC. His work at this institution has allowed him to explore innovative solutions in the field of genetics and protein modulation. His research has the potential to impact the treatment of CADASIL significantly.

Collaborations

Some of his notable coworkers include Saskia Anne-Marie Jenny Lesnik Oberstein and Garrit-Jan Boudewijn Van Ommen. Their collaborative efforts contribute to the advancement of research in the field.

Conclusion

Johannes Gregorius Dauwerse is a prominent figure in the field of medical innovation, particularly in the modulation of NOTCH3 protein expression. His patents and research have the potential to lead to significant advancements in the treatment of genetic disorders like CADASIL.