The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2016
Filed:
Jun. 12, 2015
Academisch Ziekenhuis Leiden H.o.d.n. Lumc, Leiden, NL;
Saskia Anne-Marie Jenny Lesnik Oberstein, Oegstgeest, NL;
Garrit-Jan Boudewijn van Ommen, Amsterdam, NL;
Adriana Marie Rus, Hoofddorp, NL;
Johannes Gregorius Dauwerse, Delft, NL;
ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC, Leiden, NL;
Abstract
The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 mRNA or pre-mRNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 mRNA or pre-mRNA.