Saskia Anne-Marie Jenny Lesnik Oberstein

Title: Innovator Spotlight: Saskia Anne-Marie Jenny Lesnik Oberstein

Introduction

Saskia Anne-Marie Jenny Lesnik Oberstein is a prominent inventor based in Oegstgeest, Netherlands. She has made significant contributions to the field of medical research, particularly in the modulation of NOTCH3 protein expression. Her innovative work has led to the development of methods that could potentially transform treatments for CADASIL, a genetic disorder.

Latest Patents

Saskia holds 2 patents related to her groundbreaking research. Her latest patents include "Means and methods for modulating NOTCH3 protein expression and/or the coding region of NOTCH3; compositions and use thereof in the treatment of CADASIL." This invention provides methods for modulating NOTCH3 expression, which is crucial for addressing elevated levels of NOTCH3 protein in affected cells. The method involves using an anti-sense oligonucleotide specific for NOTCH3 mRNA or pre-mRNA, thereby decreasing the production of the NOTCH3 protein or altering its coding region.

Career Highlights

Saskia is affiliated with Academisch Ziekenhuis Leiden, also known as LUMC, where she conducts her research. Her work is characterized by a strong focus on innovative solutions to complex medical challenges. She has established herself as a key figure in her field, contributing to advancements that hold promise for patients suffering from genetic disorders.

Collaborations

Throughout her career, Saskia has collaborated with notable colleagues, including Garrit-Jan Boudewijn Van Ommen and Adriana Marie Rus. These collaborations have enriched her research and expanded the impact of her inventions.

Conclusion

Saskia Anne-Marie Jenny Lesnik Oberstein is a trailblazer in the field of medical innovation, with a focus on the modulation of NOTCH3 protein expression. Her patents and research have the potential to significantly improve treatment options for CADASIL, showcasing her dedication to advancing medical science.