Joe De Angelo

Title: Joe De Angelo: Innovator in Synthetic Biology

Introduction

Joe De Angelo is a prominent inventor based in Chapel Hill, NC (US). He has made significant contributions to the field of synthetic biology, particularly in the area of enzyme inhibitors related to the shikimate pathway. His innovative work has implications for compound discovery and the development of new methodologies in biological research.

Latest Patents

Joe De Angelo holds a patent for a "Yeast synthetic biology platform for identifying shikimate pathway enzyme inhibitors." This patent provides compositions and methods for compound discovery. The invention involves modified yeast that have their endogenous shikimate pathway disrupted or deleted, and replaced with homologous pathway genes from one or more distinct organisms. These modified yeast are utilized in assays to test agents that may interfere with the function of enzymes in the shikimate pathway from organisms that are distinct from the yeast hosts. The disruption or deletion of the yeast endogenous shikimate pathway results in the yeast being incapable of producing chorismic acid.

Career Highlights

Throughout his career, Joe De Angelo has worked with notable institutions, including New York University and Neochromosome Inc. His work has been instrumental in advancing the understanding of synthetic biology and its applications in various fields.

Collaborations

Joe has collaborated with esteemed colleagues such as Jef D Boeke and Leslie A Mitchell. These partnerships have further enriched his research and contributed to the success of his innovative projects.

Conclusion

Joe De Angelo's contributions to synthetic biology and his innovative patent demonstrate his commitment to advancing scientific knowledge. His work continues to influence the field and pave the way for future discoveries.