The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2020
Filed:
Apr. 04, 2019
New York University, New York, NY (US);
Neochromosome Inc., Chapel Hill, NC (US);
The Johns Hopkins University, Baltimore, MD (US);
Jef Boeke, New York, NY (US);
Leslie Mitchell, New York, NY (US);
Joe De Angelo, Chapel Hill, NC (US);
Joel S. Bader, Bronx, NY (US);
New York University, New York, NY (US);
Neochromosome Inc., Chapel Hill, NC (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Provided are compositions and methods for compound discovery. Modified yeast that have their endogenous yeast shikimate pathway disrupted or deleted, and replaced with homologous pathway genes from one or more distinct organisms, are provided and used in assays of test agents. The homologous pathway genes are designed to supplement the disrupted or deleted shikimate pathway genes. The assays are designed to identify whether or not the test agents can interfere with the function of enzymes in the shikimate pathway from organisms that are distinct from the yeast avatar hosts. In embodiments, the disruption/deletion of the yeast endogenous shikimate pathway results in the yeast being incapable of producing chorismic acid.