Location History:
- Baltimore, MD (US) (2018)
- New York, NY (US) (2017 - 2023)
Company Filing History:
4 out of 3,688 
4 out of 1,697 
1 out of 1 Years Active: 2017-2023
Title: Innovations and Contributions of Inventor Leslie A Mitchell
Introduction
Leslie A Mitchell is a prominent inventor based in New York, NY (US), known for his significant contributions to the field of synthetic biology. With a total of 5 patents, he has made remarkable advancements in the assembly of DNA sequences and the discovery of enzyme inhibitors.
Latest Patents
One of his latest patents is titled "Extrachromosomal switching auxotrophies progressively by integration (eSwAP-In) for assembly of DNA sequences in yeast." This patent provides compositions, methods, and kits for the assembly of a series of DNA segments in yeast using homologous recombination. The assembled DNA segments are maintained episomally, and the yeast produced using these methods can be utilized to express proteins and screen test agents that may affect the modified yeast.
Another notable patent is the "Yeast synthetic biology platform for identifying shikimate pathway enzyme inhibitors." This invention includes compositions and methods for compound discovery. It features modified yeast with disrupted or deleted endogenous shikimate pathways, replaced with homologous pathway genes from distinct organisms. These modifications allow for assays to identify whether test agents can interfere with the function of enzymes in the shikimate pathway.
Career Highlights
Leslie A Mitchell has worked with prestigious institutions such as Johns Hopkins University and New York University. His work has significantly impacted the field of synthetic biology, particularly in the areas of DNA assembly and enzyme inhibition.
Collaborations
Throughout his career, Mitchell has collaborated with notable colleagues, including Jef D Boeke and Neta Agmon, who have contributed to his research endeavors.
Conclusion
Leslie A Mitchell's innovative work in synthetic biology and his numerous patents highlight his role as a leading inventor in the field. His contributions continue to influence research and development in DNA assembly and enzyme discovery.