Joanna Zuberek

Title: Joanna Zuberek: Innovator in mRNA Cap Analogs

Introduction

Joanna Zuberek is a prominent inventor based in Warsaw, Poland. She has made significant contributions to the field of molecular biology, particularly in the development of mRNA cap analogs. Her innovative work has implications for both research and therapeutic applications.

Latest Patents

Joanna Zuberek holds a patent for mRNA cap analogs. The patent describes dinucleotide cap analogs that are modified at different phosphate positions with a boranophosphate group or a phosphoroselenoate group. These analogs are useful as reagents in the preparation of capped mRNAs and exhibit increased stability both in vitro and in vivo. They may also serve as inhibitors of cap-dependent translation. Additionally, the boranophosphate or phosphoroselenoate group can have a 2'-O or 3′-O-alkyl group, preferably a methyl group, leading to the creation of analogs known as BH-ARCAs or Se-ARCAs. Furthermore, ARCAs may be modified with α-, β-, or γ-boranophosphate or phosphoroselenoate groups.

Career Highlights

Joanna Zuberek is affiliated with Louisiana State University and Agricultural & Mechanical College, where she continues her research and development efforts. Her work has garnered attention in the scientific community, contributing to advancements in mRNA technology.

Collaborations

Joanna collaborates with notable colleagues, including Joanna Kowalska and Jacek Jemielity. These partnerships enhance her research capabilities and foster innovation in her field.

Conclusion

Joanna Zuberek is a trailblazer in the development of mRNA cap analogs, with her patent showcasing her innovative contributions to molecular biology. Her work not only advances scientific understanding but also holds promise for future therapeutic applications.