The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2013
Filed:
Jun. 04, 2009
Joanna Kowalska, Radom, PL;
Jacek Jemielity, Warsaw, PL;
Edward Darzynkiewicz, Warsaw, PL;
Robert E. Rhoads, Shreveport, LA (US);
Maciej Lukaszewicz, Warsaw, PL;
Joanna Zuberek, Warsaw, PL;
Joanna Kowalska, Radom, PL;
Jacek Jemielity, Warsaw, PL;
Edward Darzynkiewicz, Warsaw, PL;
Robert E. Rhoads, Shreveport, LA (US);
Maciej Lukaszewicz, Warsaw, PL;
Joanna Zuberek, Warsaw, PL;
Board of Supervisors of Louisiana State University And Agricultural and Mechanical College, Baton Rouge, LA (US);
Abstract
Dinucleotide cap analogs are disclosed, modified at different phosphate positions with a boranophosphate group or a phosphoroselenoate group. The analogs are useful as reagents in the preparation of capped mRNAs and have increased stability both in vitro and in vivo. They may be used as inhibitors of cap-dependent translation. Optionally, the boranophosphate or phosphoroselenoate group has a 2'-O or 3′-O-alkyl group, preferably a methyl group, producing analogs called BH-ARCAs or Se-ARCAs. ARCAs may be modified with α-, β-, or γ-boranophosphate or phosphoroselenoate groups.