Jinghua Chen

Title: Innovations of Jinghua Chen

Introduction

Jinghua Chen is a notable inventor based in Wuhan, China. She has made significant contributions to the field of biochemistry, particularly in the synthesis of sulfated polysaccharides. With a total of 2 patents, her work has implications for therapeutic methods involving modified heparan sulfate.

Latest Patents

One of her latest patents focuses on the enzymatic synthesis of sulfated polysaccharides. In this patent, heparin is synthesized from a polysaccharide comprised of a 1-4 glycosidically linked alternating polymer of uronic acid and glucosamine residues. The uronic acid is selected from iduronic and glucuronic acid, while the glucosamine is partially N-sulfated. This process involves a series of selective reactions catalyzed by recombinant enzymes. Another patent involves 3-OST-5 proteins and nucleic acid molecules encoding the same. It also discloses recombinant host cells, recombinant nucleic acids, and recombinant proteins, along with methods of producing each. Additionally, isolated and purified antibodies to 3-OST-5 homologs and methods of producing them are included. The gene products of 3OST-5 have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions, providing unique modified heparan sulfate.

Career Highlights

Jinghua Chen has worked at prestigious institutions, including the University of North Carolina at Chapel Hill and the University of Illinois. Her academic background and research experience have significantly contributed to her innovative work in the field.

Collaborations

Some of her notable coworkers include Jian Liu and Guoqing Xia, who have collaborated with her on various research projects.

Conclusion

Jinghua Chen's contributions to the field of biochemistry through her patents and research collaborations highlight her role as an influential inventor. Her work continues to pave the way for advancements in therapeutic methods involving sulfated polysaccharides.