The University of North Carolina at Chapel Hill

University of Illinois

Rensselaer Polytechnic Institute

Jinghua Chen

Jian Liu

Robert J Linhardt

Deepak Shukla

Vaibhav Tiwari

Fikri Avci

Ava M Munoz

Guoqing Xia

Michael B Duncan

Heparin is synthesized from a polysaccharide comprised of a 1-4 glycosidically linked alternating polymer of uronic acid and glucosamine residues, wherein the uronic acid is selected from iduronic and glucuronic acid, wherein the glucosamine is partially N-sulfated; by a series of selective reactions catalyzed by recombinant enzymes.

Enzymatic synthesis of sulfated polysaccharides

3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.

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Growing community of inventors

Wuhan, China

Jinghua Chen