Jing Zhang

Title: Jing Zhang: Innovator in Antibody Engineering

Introduction

Jing Zhang is a prominent inventor based in Wuhan, China. She has made significant contributions to the field of biopharmaceuticals, particularly in antibody engineering. With a total of 10 patents, her work focuses on enhancing the efficacy and safety of therapeutic antibodies.

Latest Patents

Jing Zhang's latest patents include innovative developments in modified Fc fragments and multifunctional CD3 antibodies. One of her notable patents, titled "Modified Fc fragment, antibody comprising same, and application thereof," describes a modified Fc fragment derived from human IgG1. This invention features multiple substitutions in the constant region CH2 domain, which significantly reduce the binding ability of the Fc fragment to Fcγ receptors. This reduction minimizes the non-specific activation of T cells by antibodies, such as anti-CD3 antibodies. Another significant patent, "CD3 antigen binding fragment and application thereof," presents a humanized and multifunctional CD3 antibody. This antibody includes a heavy chain variable region with specific amino acid sequences and a light chain variable region that enhances its specificity for tumor cells or microorganisms. The multifunctional antibody also comprises a fusion peptide that improves biological activity, thermal stability, and acid resistance.

Career Highlights

Jing Zhang has worked with notable organizations, including Wuhan Yzy Biopharma Co., Ltd. and Huazhong University of Science and Technology. Her experience in these institutions has allowed her to advance her research and contribute to the development of innovative biopharmaceutical solutions.

Collaborations

Throughout her career, Jing Zhang has collaborated with esteemed colleagues, including Pengfei Zhou and Yongxiang Yan. These partnerships have fostered a collaborative environment that enhances the research and development of new therapeutic approaches.

Conclusion

Jing Zhang's contributions to antibody engineering and her innovative patents have positioned her as a leading figure in the biopharmaceutical industry. Her work continues to impact the development of effective therapies for various diseases.