Jing Luo

Title: Innovations of Jing Luo in Nanopore-Based Sequencing Technology

Introduction

Jing Luo is an accomplished inventor based in Daly City, CA (US). She holds a total of 9 patents that contribute significantly to the field of nanopore-based sequencing technology. Her innovative approaches have paved the way for advancements in lipid bilayer monitoring and formation.

Latest Patents

One of her latest patents is titled "Non-destructive bilayer monitoring using measurement of bilayer response to electrical stimulus." This patent discloses a method for detecting a lipid bilayer formed in a cell of a nanopore-based sequencing chip. The method involves coupling an integrating capacitor with a lipid membrane, which is positioned between a working electrode and a counter electrode. An alternating current (AC) voltage is applied to the counter electrode, and the voltage across the integrating capacitor is periodically sampled by an analog-to-digital converter (ADC). The change in the sampled voltage across the integrating capacitor in response to the AC voltage is determined, allowing for the detection of whether the lipid membrane comprises a lipid bilayer.

Another significant patent is "Electrical enhancement of bilayer formation." This invention describes a method for forming multiple lipid bilayers over an array of cells in a nanopore-based sequencing chip. The process involves flowing a salt buffer solution over the array of cells to fill the wells with the solution. A lipid and solvent mixture is then deposited over some of the wells. The method detects cells with lipid bilayers and those with lipid membranes but not bilayers. An electrical lipid-thinning stimulus is selectively applied to the cells without bilayers.

Career Highlights

Jing Luo has worked with notable companies such as Roche Sequencing Solutions, Inc. and Roche Molecular Systems, Inc. Her contributions to these organizations have been instrumental in advancing sequencing technologies.

Collaborations

Throughout her career, Jing has collaborated with esteemed colleagues, including Ashraf M Wahba and William D Nielsen. These partnerships have fostered innovation and development in her field.

Conclusion

Jing Luo's work in nanopore-based sequencing technology showcases her innovative spirit and dedication to advancing scientific research. Her patents reflect her expertise and commitment to improving lipid bilayer monitoring and formation methods.