This inventor holds 2 USPTO granted patents and 1 published patent application. Top assignee: Johns Hopkins University. Active years: 2001-2004.
Company Filing History:
Years Active: 2001-2004
Title: Jill Slansky: Innovator in Immune Response Modulation
Introduction
Jill Slansky is a prominent inventor based in Baltimore, MD (US). She has made significant contributions to the field of immunology, particularly in the development of innovative methods to detect and modulate immune responses. With a total of 2 patents, her work has implications for both research and therapeutic applications.
Latest Patents
One of her latest patents focuses on the use of multivalent chimeric peptide-loaded, MHC/Ig molecules to detect, activate, or suppress antigen-specific T cell-dependent immune responses. This invention aims to increase the effective affinity of soluble analogs of peptide/MHC molecules for their cognate ligands by constructing divalent peptide/MHC complexes. Through a recombinant DNA strategy, DNA encoding the MHC class I was ligated to DNA coding for murine Ig heavy chain. The MHC/Ig complexes were then exploited to homogeneously load with peptides of interest. Flow cytometry results demonstrated that these complexes bound specifically with high affinity to cells bearing their cognate receptors. Additionally, MHC/Ig complexes are useful in modulating effector functions of antigen-specific T cells, making them valuable for studying TCR/MHC interactions and lymphocyte tracking.
Career Highlights
Jill Slansky is affiliated with Johns Hopkins University, where she continues her research and development efforts. Her work has garnered attention for its innovative approach to immune response modulation, contributing to advancements in the field.
Collaborations
Some of her notable coworkers include Sean O'Herrin and Drew M Pardoll, who have collaborated with her on various projects related to immune responses.
Conclusion
Jill Slansky's contributions to immunology through her patents and research at Johns Hopkins University highlight her role as an influential inventor in the field. Her innovative approaches to immune response modulation have the potential to impact both scientific research and clinical applications.