Company Filing History:
Years Active: 2009-2011
Title: Jie Xia: Innovator in Oligonucleotide Technology
Introduction
Jie Xia is a prominent inventor based in Carlsbad, California, known for his significant contributions to the field of oligonucleotide technology. With a total of 5 patents, he has made remarkable advancements that have implications in various scientific and medical applications.
Latest Patents
One of Jie Xia's latest patents involves oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase. This invention describes a double-stranded oligonucleotide that includes at least one ligand attached to an altered or non-natural nucleobase, such as difluorotolyl, nitropyrrolyl, or nitroimidazolyl. The patent also explores the possibility of having both strands of the oligonucleotide independently contain a ligand tethered to a non-natural nucleobase. Additionally, it discusses single-stranded oligonucleotides with similar characteristics, emphasizing the potential for modified sugar moieties and phosphorothioate linkages.
Career Highlights
Throughout his career, Jie Xia has worked with notable companies in the biotechnology sector, including Alnylam Pharmaceuticals, Inc. and Isis Pharmaceuticals, Inc. His work in these organizations has allowed him to develop innovative solutions that push the boundaries of current scientific understanding.
Collaborations
Jie Xia has collaborated with esteemed colleagues such as Muthiah Manoharan and Kallanthottathil G Rajeev. These partnerships have fostered a collaborative environment that enhances the development of groundbreaking technologies in the field of oligonucleotides.
Conclusion
Jie Xia's contributions to oligonucleotide technology exemplify the impact of innovation in the scientific community. His patents and collaborations continue to influence advancements in biotechnology and medicine.