Jie Mao

Title: Innovations by Jie Mao in Oligonucleotide Sequencing

Introduction

Jie Mao is an accomplished inventor based in San Diego, CA. He has made significant contributions to the field of biotechnology, particularly in the area of oligonucleotide sequencing. His innovative work has led to the development of methods that enhance the efficiency and accuracy of sequencing processes.

Latest Patents

Jie Mao holds a patent titled "Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides." This patent, which is one of his notable achievements, focuses on methods for preparing templates for polynucleotide sequencing. The invention specifically addresses the linearization of clustered polynucleotides by cleaving strands of double-stranded polynucleotides immobilized on a solid support using transition metal complexes, such as palladium or nickel complexes. Additionally, the patent discusses the removal of blocking groups from nucleotides and oligonucleotides, further advancing the field of genetic research.

Career Highlights

Throughout his career, Jie Mao has worked with prominent companies in the biotechnology sector, including Illumina Corporation and Illumina Cambridge Limited. His experience in these organizations has allowed him to collaborate with leading experts and contribute to groundbreaking advancements in sequencing technologies.

Collaborations

Jie Mao has collaborated with notable professionals in his field, including Xiaolin Wu and Randall Smith. These partnerships have facilitated the exchange of ideas and fostered innovation in the development of sequencing methods.

Conclusion

Jie Mao's contributions to the field of biotechnology, particularly through his patent on oligonucleotide sequencing, highlight his role as a key innovator. His work continues to influence advancements in genetic research and sequencing technologies.