Jiaohua Lin

Title: Jiaohua Lin: Innovator in Biocatalysis and Pharmaceutical Intermediates

Introduction

Jiaohua Lin is a prominent inventor based in Zhejiang, China. He has made significant contributions to the field of biocatalysis, particularly in the preparation of pharmaceutical intermediates. His innovative work has led to the development of a transaminase mutant that enhances the efficiency of synthesizing important drug components.

Latest Patents

Jiaohua Lin holds a patent for a transaminase mutant and its application in the preparation of sitagliptin intermediates. The patent describes a transaminase mutant achieved through specific amino acid substitutions, which include the replacement of tyrosine with proline at position 74, glutamic acid with aspartic acid at position 228, leucine with alanine at position 254, and methionine with threonine at position 290 of the amino acid sequence shown in SEQ ID NO: 2. This invention utilizes either wet cells or a purified transaminase as a biocatalyst, along with a sitagliptin precursor ketone or a prochiral carbonyl compound as a substrate. The method boasts a total yield of approximately 82%, with an enantiomeric excess (e.e.) value of the product reaching 99%.

Career Highlights

Throughout his career, Jiaohua Lin has worked with notable organizations, including Zhejiang Yongtai Technology Co., Ltd. and Zhejiang University. His experience in these institutions has allowed him to refine his expertise in biocatalysis and pharmaceutical applications.

Collaborations

Jiaohua Lin has collaborated with esteemed colleagues such as Zhiqiang Liu and Feng Cheng. These partnerships have contributed to the advancement of his research and the successful development of his patented technologies.

Conclusion

Jiaohua Lin's innovative work in biocatalysis and pharmaceutical intermediates exemplifies the impact of scientific research on drug development. His contributions continue to influence the field and pave the way for future advancements.