Jianmiao Xu

Title: **Innovator Jianmiao Xu: Pioneering Advances in Biocatalysis**

Introduction

Jianmiao Xu is a notable inventor based in Zhejiang, China, recognized for his innovative work in the field of biocatalysis. With a portfolio of seven patents, Xu has made significant contributions to the science of enzyme catalysis, particularly in the asymmetric preparation of L-phosphinothricin, a compound with notable applications in agriculture and biotechnology.

Latest Patents

Xu's recent patents highlight his expertise and creativity in enzymatic reactions:

1. **Method for Asymmetrically Preparing L-Phosphinothricin by Oxidation-Reduction Reaction Through Biological Multi-Enzyme Coupling**: This method involves a complex enzyme catalysis system wherein D,L-phosphinothricin serves as a raw material. Using a D-amino acid oxidase mutant, Xu enhances the efficiency of converting D,L-phosphinothricin into L-phosphinothricin. The innovative approach significantly increases the conversion rate and yield compared to wild-type enzymes, showcasing the potential of engineered enzymes in industrial applications.

2. **Phosphinothricin Dehydrogenase Mutant, Genetically Engineered Bacterium and One-Pot Multi-Enzyme Synchronous Directed Evolution Method**: In this patent, Xu describes a phosphinothricin dehydrogenase mutant with specific amino acid alterations that improve its functional properties. This invention also introduces a one-pot multi-enzyme synchronous directed evolution method that allows for the screening of recombinant bacteria with enhanced activity. This method stands out for its efficiency, achieving nearly 100% conversion and high stereo selectivity in reactions.

Career Highlights

Jianmiao Xu is affiliated with Zhejiang University, where he continues to push the boundaries of enzyme technology and biocatalysis. His dedication to research has positioned him as a leading figure in his field, and his patents are a testament to his commitment to innovation.

Collaborations

Throughout his career, Xu has collaborated with fellow innovators such as Yaping Xue and Feng Cheng. These collaborations have enabled the exchange of ideas and the development of advanced enzymatic processes, further enhancing the impact of their collective work.

Conclusion

Jianmiao Xu's innovative contributions to biocatalysis place him at the forefront of scientific advancement in his field. His recent patents not only demonstrate his technical expertise but also reflect a commitment to advancing biotechnological applications that can have far-reaching benefits in agriculture and industry. As he continues to explore the potential of enzymes, the scientific community eagerly anticipates his future breakthroughs.