Location History:
- Hamilton, MA (US) (2010 - 2022)
- San Diego, CA (US) (2017 - 2022)
Company Filing History:
13 out of 59 
6 out of 15,458 
Years Active: 2010-2025
Title: **Innovator Jian Yu: Advancing Cancer Detection Through Patented Inventions**
Introduction
Jian Yu, an inventive mind based in Hamilton, MA, has made significant contributions to cancer research through his 13 patents. Known for his pioneering work in molecular biology, Yu's innovations focus on detecting mutations related to lung cancer, particularly through the identification of anaplastic lymphoma kinase (ALK) fusion proteins.
Latest Patents
Yu's latest patents revolve around the detection of mutant anaplastic lymphoma kinase in human lung cancer. He has identified novel gene deletions and translocations on chromosome 2 that result in fusion proteins, such as the EML4-ALK fusion protein, which has been shown to drive the proliferation and survival of non-small cell lung carcinoma (NSCLC). These inventions provide isolated polynucleotides and vectors encoding mutant ALK kinase polypeptides. Furthermore, they include probes for detection, isolated mutant polypeptides, recombinant polypeptides, and reagents for identifying fusion and truncated polypeptides. Importantly, Yu's work enables methods for screening compounds that inhibit these proteins and offers strategies for inhibiting cancer progression characterized by mutant polynucleotides or polypeptides.
Career Highlights
Jian Yu's innovative journey is underscored by his role at Cell Signaling Technology, Inc., where he has contributed to the advancements in technologies related to cancer diagnostics. His work is instrumental in understanding the mutations that underlie various solid tumors, leading to improved detection and treatment approaches.
Collaborations
Throughout his career, Yu has collaborated with renowned researchers, including Ting-Lei Gu and Klarisa Rikova. These partnerships have bolstered his research, fostering an environment of innovation and collaboration that drives the field of cancer research forward.
Conclusion
Jian Yu stands as a prominent figure in the realm of cancer research, with a notable portfolio of patents that reflect his commitment to innovation. His discoveries, particularly regarding ALK mutations in lung cancer, hold promise for enhancing diagnostic capabilities and therapeutic strategies, paving the way for improved patient outcomes in oncological care.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.