Ji-Shuo Chang

Title: Ji-Shuo Chang: Innovator in Targeted DNA Demethylation

Introduction

Ji-Shuo Chang is a prominent inventor based in Guangzhou, China. He has made significant contributions to the field of genetic engineering, particularly in the area of targeted DNA demethylation. His innovative approaches have the potential to advance therapeutic strategies in various medical applications.

Latest Patents

Ji-Shuo Chang holds a patent for a targeted DNA demethylation method, which includes a fusion protein and its applications. This preliminary class patent, known as Mini-CRISD, provides a method for targeted delivery of demethylation activity. The Mini-CRISD method utilizes engineered miniature dCjCas9 to deliver the engineered miniature ROS1 demethylation effector to specific DNA sequences and genomic locations, such as CpG islands. This innovative approach aims to achieve targeted demethylation of specific DNA, which could have profound implications for genetic research and therapy.

Career Highlights

Throughout his career, Ji-Shuo Chang has been associated with notable institutions, including Guangzhou Medical University and Gmu New Drug Development Co., Ltd. His work in these organizations has allowed him to collaborate with other experts in the field and contribute to groundbreaking research.

Collaborations

Ji-Shuo Chang has worked alongside esteemed colleagues such as Xi-Yong Yu and Yu-Guang Zhu. Their collaborative efforts have furthered advancements in genetic engineering and therapeutic applications.

Conclusion

Ji-Shuo Chang's innovative work in targeted DNA demethylation exemplifies the potential of modern genetic engineering. His contributions are paving the way for future advancements in the field, making him a notable figure in the realm of scientific innovation.