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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11965187 B1

PDFFull Text
Date of Patent:
Apr. 23, 2024

Filed:

Jan. 17, 2023

Targeted dna demethylation method, fusion protein and application thereof preliminary class

Applicants:

Guangzhou Medical University, Guangzhou, CN;

Gmu New Drug Development Co., Ltd., Guangzhou, CN;

Inventors:

Xi-Yong Yu, Guangzhou, CN;

Yu-Guang Zhu, Guangzhou, CN;

Ao Shen, Guangzhou, CN;

Ling-Min Zhang, Guangzhou, CN;

Ji-Shuo Chang, Guangzhou, CN;

Assignees:

GUANGZHOU MEDICAL UNIVERSITY, Guangzhou, CN;

GMU NEW DRUG DEVELOPMENT CO., LTD., Guangzhou, CN;

Attorney:

Zhigang Ma

Primary Examiner:

Celine X Qian

Assistant Examiner:

Tiffany Nicole Grooms

Int. Cl.
CPC ...
C12N 9/22 (2006.01); A61K 48/00 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61K 48/0008 (2013.01); A61K 48/005 (2013.01); C12N 15/85 (2013.01); C07K 2319/09 (2013.01); C12N 2310/20 (2017.05);
Abstract

A targeted DNA demethylation method (Mini-CRISD) and a fusion protein used in the method are provided. The Mini-CRISD method can targets delivery of demethylation activity through engineered miniature dCjCas9 to deliver engineered miniature ROS1 demethylation effector to specific DNA sequences and/or specific genomic locations (such as CpG islands) to achieve targeted demethylation of specific DNA.

Find Patent Forward Citations

Yu, Xi-Yong. (2024). Targeted dna demethylation method, fusion protein and application thereof preliminary class (U.S. Patent No. 11965187). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11965187

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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