Jessica L Klockow

Title: Innovations by Jessica L Klockow

Introduction

Jessica L Klockow is an accomplished inventor based in Columbia, MO (US). She has made significant contributions to the field of molecular imaging and biosensors, holding a total of 2 patents. Her work focuses on developing advanced technologies that enhance the detection and visualization of biological processes.

Latest Patents

One of her latest patents is titled "Rhodol fluorophores for near-infrared imaging." This invention encompasses a novel near-infrared-emitting molecular fluorophore and probes that are advantageous for both in vitro and in vivo research studies. The fluorophore is robust, photostable, and designed for easy bioorthogonal conjugation. It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores can be used to fluorescently tag biological molecules or structures of interest, serving as optical reporters for specific biomarkers. The near-infrared emission is highly penetrating, making it suitable for cellular assays and preclinical small animal imaging, with potential applications in clinical settings.

Another significant patent is "pH-sensitive fluorescent sensors for biological amines." This invention focuses on dual-analyte fluorescent chemosensors that enable the direct detection and visualization of neurotransmitters released during exocytosis. The sensor takes advantage of the high concentration of neurotransmitters and the pH gradient between the vesicle and synaptic cleft, providing a powerful tool for studying neurotransmitter dynamics.

Career Highlights

Jessica has worked at prestigious institutions, including the University of Missouri and Stanford University. Her research has significantly advanced the understanding of molecular interactions and biological imaging techniques.

Collaborations

Throughout her career, Jessica has collaborated with notable colleagues, including Kenneth Hettie and Timothy E Glass. These collaborations have further enriched her research and contributed to her innovative inventions.

Conclusion

Jessica L Klockow is a pioneering inventor whose work in molecular imaging and biosensors has the potential to transform research methodologies in biology and medicine. Her contributions are invaluable to the scientific community and continue to inspire future innovations.