The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2018
Filed:
Aug. 01, 2014
Applicant:
The Curators of the University of Missouri, Columbia, MO (US);
Inventors:
Timothy E Glass, Columbia, MO (US);
Kevin D Gillis, Columbia, MO (US);
Kenneth S Hettie, Columbia, MO (US);
Jessica L Klockow, Columbia, MO (US);
Assignee:
The Curators of the University of Missouri, Columbia, MO (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 311/16 (2006.01); G01N 33/74 (2006.01);
U.S. Cl.
CPC ...
C07D 311/16 (2013.01); G01N 33/74 (2013.01);
Abstract
The invention is directed to dual-analyte fluorescent chemosensors for the direct detection and visualization (imaging) of neurotransmitters released upon exocytosis. The inventive sensor exploits the high concentration of neurotransmitters (e.g., glutamate, norepinephrine, and dopamine) and capitalizes upon the pH gradient between the vesicle and synaptic cleft.