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Years Active: 2013
Title: The Innovative Contributions of Jérôme Larghero
Introduction
Jérôme Larghero is a notable inventor based in Boulogne-Billancourt, France. He has made significant strides in the field of regenerative medicine, particularly in the development of cardiovascular progenitor cells. His work is characterized by a commitment to advancing clinical applications through innovative methodologies.
Latest Patents
Larghero holds a patent titled "Method for generating primate cardiovascular progenitor cells for clinical use from primate embryonic stem cells or embryonic-like state cells, and their applications." This invention focuses on the in vitro preparation of cardiovascular progenitor cells from mammalian embryonic stem cells or embryonic-like state cells. The method utilizes the CD15 (SSEAI) marker as a positive differentiation marker for cardiovascular progenitors. Additionally, it incorporates the use of receptor tyrosine kinase inhibitors, such as SU5402 or SU11248, in conjunction with BMP2 to enhance differentiation efficiency. The invention also explores the use of platelet lysate as a substitute for fetal animal serum in culture media, aimed at maintaining the pluripotency of primate embryonic stem cells.
Career Highlights
Throughout his career, Jérôme Larghero has worked with prestigious institutions, including Assistance Publique-Hôpitaux de Paris and the Institut National de la Santé et de la Recherche Médicale. His contributions to the field have been recognized for their potential impact on clinical practices and regenerative therapies.
Collaborations
Larghero has collaborated with esteemed colleagues such as Philippe Menasche and Michel Puceat. These partnerships have further enriched his research and development efforts in the field of cardiovascular medicine.
Conclusion
Jérôme Larghero's innovative work in generating cardiovascular progenitor cells represents a significant advancement in regenerative medicine. His patent and collaborations highlight his dedication to improving clinical outcomes through scientific innovation.