Jennifer McCaffrey

Title: Innovations of Jennifer McCaffrey

Introduction

Jennifer McCaffrey is a notable inventor based in Collegeville, PA (US). She has made significant contributions to the field of molecular biology, particularly in the area of nucleic acid labeling using CRISPR/Cas technology. With a total of two patents to her name, her work has the potential to advance genetic research and diagnostics.

Latest Patents

Jennifer's latest patents include innovative methods for specifically labeling nucleic acids using CRISPR/Cas. One of her patents describes a method for detecting the length of an individual telomere. This method involves contacting genomic DNA with a guide RNA that is complementary to a telomere repeat sequence, along with Cas9 nickase to create a single-strand break in the DNA. The process continues with the incorporation of fluorescently labeled nucleotides into the nicked DNA, allowing for the detection of telomere length through fluorescence measurement. Another patent focuses on detecting a target nucleic acid sequence using a similar approach, where the genomic DNA is treated with guide RNA and Cas9 nickase, followed by the incorporation of fluorescently labeled nucleotides to identify the target sequence.

Career Highlights

Throughout her career, Jennifer has worked with esteemed institutions such as Drexel University and The Wistar Institute of Anatomy & Biology. Her research has contributed to the understanding of genetic sequences and their applications in various scientific fields.

Collaborations

Jennifer has collaborated with notable colleagues, including Ming H Xiao and Harold C Riethman. These partnerships have further enhanced her research and innovation in the field of molecular biology.

Conclusion

Jennifer McCaffrey's work in the realm of CRISPR/Cas technology showcases her innovative spirit and dedication to advancing genetic research. Her contributions are paving the way for future discoveries in molecular biology and diagnostics.