Company Filing History:
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Years Active: 2009-2010
Title: Jennifer Jones McIntire: Innovator in Immune Regulation
Introduction
Jennifer Jones McIntire is a prominent inventor based in Palo Alto, CA (US). She has made significant contributions to the field of immunology, particularly in understanding the genetic factors associated with immune diseases. With a total of 2 patents, her work has implications for various immune dysfunctions.
Latest Patents
McIntire's latest patents include groundbreaking research on T cell regulatory genes associated with immune disease. One patent describes a genetic locus and corresponding family of proteins that regulate immune development, function, and cell survival. This locus, comprising the TIM family, is genetically linked to immune dysfunctions such as atopy, autoimmunity, inflammatory bowel disease, dysplasia, and susceptibility to blood-borne infectious diseases. Notably, polymorphisms in the human TIM-1 gene have been shown to correlate with protection against the development of atopy when exposed to Hepatitis A Virus (HAV).
Another patent focuses on T cell regulatory genes and their methods of use. This patent highlights a genetic locus and family of proteins that are crucial for regulating immune function and cell survival. The genes encode cell surface molecules with conserved IgV and mucin domains. The TIM gene family is located within a region of human chromosome 5 that is often deleted in malignancies and myelodysplastic syndrome. Polymorphisms in these gene sequences are associated with airway hyperreactivity and allergic inflammation, as well as T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
Career Highlights
Throughout her career, McIntire has worked with esteemed institutions such as Leland Stanford Junior University and Dana-Farber Cancer Institute Inc. Her research has significantly advanced the understanding of immune regulation and its associated disorders.
Collaborations
Some of her notable collaborators include Rosemarie Dekruyff and Dale T Umetsu. Their combined expertise has contributed to the success of various research projects in the field of immunology.
Conclusion
Jennifer Jones McIntire's innovative work in the realm of immune regulation has paved the way for new insights into immune diseases. Her patents reflect her commitment to advancing scientific knowledge and improving health outcomes.