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1 out of 5 Years Active: 2000-2008
Title: The Innovative Contributions of Jeffrey Wrana
Introduction
Jeffrey Wrana is a prominent inventor based in Toronto, Canada, known for his significant contributions to the field of molecular biology. With a total of 3 patents, he has made remarkable advancements in understanding cellular signaling pathways.
Latest Patents
One of his latest patents focuses on modulators of Smurf and BMP/TGFβ signaling pathways. This invention introduces unique members of the Hect family of ubiquitin ligases that specifically target BMP and TGFβ/activin pathway-specific Smads. The novel ligases, named Smurf1 and Smurf2, directly interact with Smads1 and 5 and Smad7, respectively. They regulate the ubiquitination, turnover, and activity of Smads and other proteins involved in these pathways. Smurf1 interferes with biological responses to BMP, while Smurf2 suppresses TGFβ signaling. This research provides a unique regulatory link between the ubiquitination pathway and the control of cell fate determination during embryonic development.
Career Highlights
Throughout his career, Jeffrey Wrana has worked with notable companies such as Signal Pharmaceuticals, Inc. and HSC Research and Development Limited Partnership. His work has significantly impacted the understanding of cellular mechanisms and their implications in developmental biology.
Collaborations
Jeffrey has collaborated with esteemed colleagues, including Gerald H. Thomsen and Liliana Attisano, further enhancing the depth and breadth of his research contributions.
Conclusion
Jeffrey Wrana's innovative work in the field of molecular biology has led to important discoveries in cellular signaling pathways. His patents and collaborations continue to influence research and development in this critical area of science.