Jean Louis Junien

Title: The Innovations of Jean Louis Junien

Introduction

Jean Louis Junien is a notable inventor based in Sèvres, France. He has made significant contributions to the field of opioid research, particularly through his innovative work on kappa receptor opioid peptides. His research focuses on developing peptides that exhibit high selectivity for the kappa opioid receptor (KOR), which has important implications for pain management and therapeutic applications.

Latest Patents

Jean Louis Junien holds a patent for his invention related to kappa receptor opioid peptides. This patent describes peptides that demonstrate high selectivity for the KOR and possess a long duration of peripheral action without significant entry into the brain. The sequences consist of four D-isomer amino acid residues with a C-terminus that is a mono or di-substituted amide. The representative compounds have an affinity for the KOR that is at least 1,000 times greater than their affinity for the mu opioid receptor, with an ED.sub.50 of not greater than about 0.5 mg/kg.

Career Highlights

Throughout his career, Jean Louis Junien has been associated with Ferring B.V., a company known for its focus on innovative pharmaceuticals. His work has contributed to advancements in the understanding and application of opioid peptides in medical science.

Collaborations

Jean Louis Junien has collaborated with notable colleagues, including Pierre Jm Riviere and Javier Sueiras Diaz. These collaborations have further enriched his research and development efforts in the field of opioid peptides.

Conclusion

Jean Louis Junien's innovative work in the development of kappa receptor opioid peptides highlights his significant contributions to medical science. His patent and collaborations reflect a commitment to advancing therapeutic options for pain management.