The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 1999
Filed:
Dec. 23, 1997
Applicant:
Inventors:
Jean Louis Junien, Sevres, FR;
Pierre JM. Riviere, San Diego, CA (US);
Claudio D Schteingart, La Jolla, CA (US);
Javier Sueiras Diaz, La Jolla, CA (US);
Jerzy A Trojnar, Solana Beach, CA (US);
Todd W Vanderah, Tucson, AZ (US);
Assignee:
Ferring BV, , NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ;
U.S. Cl.
CPC ...
530330 ; 514-2 ; 514 18 ;
Abstract
Peptides which exhibit high selectivity for the kappa opioid receptor (KOR) and long duration of peripheral action without significant entry into the brain are created which are sequences of four D-isomer amino acid residues having a C-terminus which is a mono or di-substituted amide. Representative compounds, which have an affinity for the KOR at least 1,000 times their affinity for the mu opioid receptor and an ED.sub.50 of not greater than about 0.5 mg/kg, include