Location History:
- Faches-Thumesnil, FR (2008 - 2010)
- Lille, FR (2020)
Company Filing History:
2 out of 5,089 
1 out of 38 
1 out of 55 
Years Active: 2008-2020
Title: The Innovations of Jean Dubuisson
Introduction
Jean Dubuisson is a notable inventor based in Faches-Thumesnil, France. He has made significant contributions to the field of virology, particularly in relation to hepatitis viruses. With a total of 3 patents, his work has had a substantial impact on the understanding and diagnosis of viral infections.
Latest Patents
One of Dubuisson's latest patents focuses on the Hepatitis E virus ORF2 capsid polypeptides and their uses. Hepatitis E virus (HEV) is responsible for over 50% of acute viral hepatitis cases worldwide. The inventors have identified the precise sequence of infectious particle-associated ORF2 capsid protein. Their analyses revealed that in infected patients, HEV produces three forms of the ORF2 capsid protein: ORF2i, ORF2g, and ORF2c. The ORF2i protein is associated with infectious particles, whereas ORF2g and ORF2c proteins are glycoproteins that are not associated with infectious particles and are the major antigens present in HEV-infected patient sera. Accordingly, the ORF2i and ORF2g proteins, along with antibodies specific for these proteins and diagnostic assays (e.g., ELISA) for diagnosing Hepatitis E virus infection, are the subject matter of this invention. Another significant patent involves nucleotide sequences coding for the non-structural proteins of the hepatitis C virus. This invention concerns the use of cells capable of carrying out a process of prenylation of proteins coded by the hepatitis C virus (HCV) genome, such as prenylation of the NS5A protein, for replicating and producing HCV or derivative viable mutants in a suitable culture medium.
Career Highlights
Throughout his career, Dubuisson has worked with prestigious organizations, including the National Centre for Scientific Research (Centre National De La Recherche Scientifique) and the National Institute of Health and Medical Research (Inserm). His research has contributed to advancements in the understanding of hepatitis viruses and their mechanisms.
Collaborations
Jean Dubuisson has collaborated with notable colleagues, including Czeslaw Wychowski and Gilles Duverlie. Their joint efforts have furthered research in the field of virology and have led to significant discoveries.
Conclusion
Jean Dub