The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Jan. 29, 2018
Inserm (Institut National DE LA Santéet DE LA Recherche Médicale), Paris, FR;
Institut Pasteur DE Lille, Lille, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Universitéde Lille, Lille, FR;
Centre Hospitalier Regional Universitaire DE Lille, Lille, FR;
Laurence Cocquerel-Deproy, Lille, FR;
Claire Montpellier, Lille, FR;
Jean Dubuisson, Lille, FR;
Anne Goffard, Lille, FR;
INSERM (Institut National de la Santé´et de la Recherche Médicale), Paris, FR;
Institut Pasteur de Lille, Lille, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Universitë{umlaut over ( )}de Lille, Lille, FR;
Centre Hospitalier Regional Universitaire de Lille, Lille, FR;
Abstract
Hepatitis E virus (HEV) is responsible for over 50% of acute viral hepatitis cases worldwide. The inventors have now identified the precise sequence of infectious particle-associated ORF2 capsid protein. Strikingly, their analyses revealed that in infected patients, HEV produces three forms of the ORF2 capsid protein: ORF2i, ORF2g and ORF2c. The ORF2i protein is associated with infectious particles whereas ORF2g and ORF2c proteins are massively produced glycoproteins that are not associated with infectious particles and are the major antigens present in HEV-infected patient sera. Accordingly, the ORF2i and ORF2g proteins are thus the subject matter of the present invention as well as antibodies specific for the proteins and diagnostic assays (e.g. ELISA) for the diagnosis of Hepatitis E virus infection.