Company Filing History:
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Years Active: 2015-2018
Title: Innovator Profile: Jay L. Hess – A Visionary in Cancer Research
Introduction
Jay L. Hess is a distinguished inventor based in Ann Arbor, Michigan, with a significant contribution to the field of cancer research. With a total of six patents to his name, Hess is recognized for his innovative work in developing compounds and methods aimed at inhibiting oncogenic interactions that contribute to cancer progression.
Latest Patents
Among his latest innovations are two pivotal patents. The first involves "Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof." This disclosure pertains to methods that inhibit the interaction of menin with MLL1, MLL2, and MLL-fusion oncoproteins. The compounds outlined provide promising avenues for therapeutic applications in hematological malignancies.
The second patent relates to "Compositions and methods relating to hindering DOT1L recruitment by MLL-fusion proteins." This invention focuses on MLL fusion proteins, such as AF9 and ENL, which activate target genes partly through the recruitment of the histone methyltransferase DOT1L. Hess’s work here details proteins that block the interactions between AF9/ENL and DOT1L, thereby inhibiting the associated pathway involved in MLL-fusion protein-driven leukemia.
Career Highlights
Jay L. Hess has built his career at renowned institutions including the University of Michigan and the University of Virginia. His tenure at these esteemed universities has allowed him to pursue groundbreaking research and enhance his expertise in medicinal chemistry and cancer biology.
Collaborations
Throughout his career, Hess has collaborated with remarkable colleagues in the field, including Jolanta Grembecka and Tomasz Cierpicki. These partnerships have not only fostered intellectual growth but also led to significant advancements in cancer treatment methodologies.
Conclusion
With a robust portfolio of patents and a dedication to medical advancement, Jay L. Hess exemplifies the spirit of innovation in the fight against cancer. His work continues to shape the future of therapeutic strategies, one compound at a time. As the landscape of cancer research evolves, Hess's contributions will undoubtedly leave a lasting impact on the scientific community.