Jason N Belling

Title: Jason N Belling: Innovator in Microfluidic Technology

Introduction

Jason N Belling is a prominent inventor based in Los Angeles, CA. He has made significant contributions to the field of microfluidics, particularly in the area of intracellular delivery systems. With a total of 2 patents, his work focuses on innovative methods for enhancing the delivery of biomolecular cargo into cells.

Latest Patents

Belling's latest patents include a high-throughput system and method for the temporary permeabilization of cells using lipid bilayers. This microfluidic device is designed to process cells for the intracellular delivery of molecules or other cargo. The device features one or more microchannels that are fluidically coupled to an inlet, allowing for the introduction of a solution containing the cells and the desired cargo. Each microchannel contains constriction regions with lipid bilayers, facilitating the delivery of gene-editing molecules into cells.

Another notable patent is a device and method for intracellular delivery of biomolecular cargo via acoustic wave exposure. This microfluidic-based system enables high-throughput delivery of biomolecular cargo to various cell types or enveloped viruses. The integration of cargo occurs through transient membrane permeabilization, achieved by exposing cells to bulk acoustic waves generated by a rapidly oscillating piezoelectric substrate. This innovative approach establishes temporary pores across the cellular membrane, enhancing the efficiency of cargo delivery.

Career Highlights

Throughout his career, Jason N Belling has worked with esteemed institutions such as the University of California and Nanyang Technological University. His research has significantly advanced the understanding and application of microfluidic technologies in biological systems.

Collaborations

Belling has collaborated with notable individuals in the field, including Paul S Weiss and Steven J Jonas. These partnerships have contributed to the development of groundbreaking technologies in microfluidics and cellular biology.

Conclusion

Jason N Belling is a key figure in the innovation of microfluidic technologies, with a focus on enhancing intracellular delivery methods. His patents reflect a commitment to advancing scientific knowledge and practical applications in the field.