Jason Marc Goldstein

Title: Jason Marc Goldstein: Innovator in Biomedical Research

Introduction

Jason Marc Goldstein is a prominent inventor based in Decatur, GA (US). He has made significant contributions to the field of biomedical research, particularly in the study of neurodegenerative diseases and bacterial toxins. With a total of 6 patents, Goldstein's work has the potential to impact drug discovery and therapeutic approaches.

Latest Patents

One of Goldstein's latest patents focuses on "Antibodies to alpha synuclein." This application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models. These diseases are characterized by aggregations of alpha-synuclein. The fragments identified have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa, as determined by SDS gel electrophoresis in tricine buffer, and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments has numerous applications in drug discovery, diagnostics, therapeutics, and transgenic animals. Another significant patent involves "Regulating Bacillus anthracis lethal factor activity via an activating epitope region." This patent provides antibodies capable of binding to a specific epitope or binding to LF or LTx, enhancing their activity relative to the absence of antibody binding.

Career Highlights

Goldstein has worked with notable companies in the pharmaceutical industry, including Elan Pharmaceuticals, Inc. and Elan Pharma International Limited. His experience in these organizations has contributed to his expertise in developing innovative solutions for complex biomedical challenges.

Collaborations

Throughout his career, Goldstein has collaborated with esteemed colleagues, including Tamie Chilcote and John P Anderson. These partnerships have fostered a collaborative environment that encourages the exchange of ideas and advancements in research.

Conclusion

Jason Marc Goldstein is a distinguished inventor whose work in biomedical research continues to pave the way for advancements in understanding and treating neurodegenerative diseases. His innovative patents and collaborations highlight his commitment to improving healthcare outcomes.