The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2007
Filed:
Oct. 19, 2004
Tamie J Chilcote, San Francisco, CA (US);
Jason Goldstein, Burlingame, CA (US);
John P Anderson, San Francisco, CA (US);
Wei Ping Gai, Hazelwood Park, AU;
Tamie J Chilcote, San Francisco, CA (US);
Jason Goldstein, Burlingame, CA (US);
John P Anderson, San Francisco, CA (US);
Wei Ping Gai, Hazelwood Park, AU;
Elan Pharmaceuticals, Inc., South San Francisco, CA (US);
The Trustees of Flinders University, Adelaide, AU;
Abstract
The application identifies fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.