Company Filing History:
Years Active: 2023-2025
Title: Innovations by Jason L Dehart
Introduction
Jason L Dehart is an accomplished inventor based in San Diego, California. He has made significant contributions to the field of biotherapeutics through his innovative patents. With a total of three patents to his name, Dehart's work focuses on enhancing gene expression and developing RNA replicons for therapeutic applications.
Latest Patents
One of Dehart's latest patents is titled "Alphavirus-based replicons for administration of biotherapeutics." This invention provides RNA replicons that are useful for administering a heterologous protein or peptide into a mammal while eliciting a reduced immune response or no immune response from the mammal. The RNA replicons contain RNA sequences encoding for a heterologous protein or peptide, New World alphavirus nonstructural proteins nsP1, nsP2, and nsP4, along with an alphavirus nsP3 protein macro domain, central domain, and hypervariable domain. The encoded hypervariable domain can have an amino acid sequence derived from an Old World alphavirus nsP3 hypervariable domain or can have an amino acid sequence derived from a portion of a New World alphavirus nsP3 hypervariable domain, and another portion derived from an Old World alphavirus nsP3 hypervariable domain.
Another significant patent is "Compositions and methods for enhancing gene expression." This disclosure relates to nucleic acid molecules that are used in regulating gene expression. The nucleic acid molecules include one or more structural elements of the viral capsid enhancer operably linked to a coding sequence of a gene of interest. In some embodiments, the viral capsid enhancer comprises a Downstream Loop (DLP) from a viral capsid protein or a variant of the DLP.
Career Highlights
Jason L Dehart is currently employed at Janssen Pharmaceuticals, Inc., where he continues to innovate in the field of biotherapeutics. His work has the potential to significantly impact the development of new treatments and therapies.
Collaborations
Dehart collaborates with notable colleagues such as Nathaniel Stephen Wang and Kurt Iver Kamrud. Their combined expertise contributes to the advancement of their research and innovations.
Conclusion
Jason L Dehart is a prominent inventor whose work in biotherapeutics is paving the way for new medical advancements. His innovative patents demonstrate his commitment to enhancing gene expression and developing effective therapeutic solutions.