Jared C Lewis

Title: The Innovative Mind of Jared C. Lewis

Introduction

Jared C. Lewis, an accomplished inventor based in Chicago, IL, is recognized for his significant contributions in the field of biochemistry and enzymology. With an impressive portfolio of six patents, Lewis has been at the forefront of developing innovative methods and reagents that push the boundaries of chemical synthesis.

Latest Patents

Among his latest patents, one titled "Cytochrome P450 BM3 enzyme variants for preparation of cyclopropanes" stands out. This invention presents novel methods for catalyzing the conversion of olefins into compounds that feature cyclopropane functional groups using heme enzymes. The invention details a process that combines an olefinic substrate, a diazo reagent, and a heme enzyme under specific conditions to yield cyclopropanation products. Furthermore, it introduces variants and fragments of heme enzymes that facilitate these reactions, including the development of expression vectors and host cells equipped to express these innovative enzymes.

Another significant patent by Lewis is "Directed evolution of a regioselective halogenase for increased thermostability." This patent describes compounds and methodologies resulting from the directed evolution of RebH variants. These variants exhibit enhanced thermostability and increased activity at elevated temperatures, showcasing Lewis's commitment to pushing the limits of enzyme functionality through random mutagenesis.

Career Highlights

Jared C. Lewis has greatly influenced the fields of enzyme engineering and biocatalysis through his work in esteemed institutions. He has made substantial contributions during his tenure at the California Institute of Technology and The Scripps Research Institute. His innovative research has not only garnered patents but has also established him as a leader in developing revolutionary enzymatic applications.

Collaborations

Throughout his career, Lewis has collaborated with prominent figures in the scientific community, including notable scientists Frances H. Arnold and Pedro S. Coelho. These collaborations have fostered a rich environment for research and development, resulting in advancements that have had a lasting impact on the field.

Conclusion

Jared C. Lewis exemplifies the spirit of innovation through his prolific inventiveness and dedication to advancing biochemistry. With six patents to his name, his contributions are paving the way for future research and development within the realm of enzymatic reactions and synthetic methodologies. As he continues to explore new horizons in his field, the scientific community eagerly anticipates his future endeavors and the innovations that will follow.