Janet Connolly

Title: Innovations by Janet Connolly

Introduction

Janet Connolly is a notable inventor based in North Potomac, MD (US). She has made significant contributions to the field of immunology through her innovative work on disulfide trap MHC class I molecules. Her research has implications for vaccination and T cell tracking, showcasing her expertise in the area.

Latest Patents

Janet Connolly holds a patent for a disulfide trap, which comprises an antigen peptide covalently attached to an MHC class I heavy chain molecule by a disulfide bond extending between two cysteines. This invention allows for the proper oxidation of the disulfide trap in the endoplasmic reticulum, enabling recognition by T cells. The patent also discusses various configurations of the disulfide trap, including its use for vaccination to elicit CD8 T cells and in multivalent MHC/peptide reagents for T cell enumeration and tracking. Additionally, nucleic acids encoding the disulfide trap can be utilized as DNA vectors for vaccine development.

Career Highlights

Janet Connolly's career is marked by her dedication to advancing immunological research. Her innovative patent reflects her commitment to developing new methods for enhancing immune responses. Working at Washington University, she has been able to collaborate with other experts in the field, furthering her research and its applications.

Collaborations

Janet has collaborated with notable colleagues such as Ted H Hansen and Daved Henry Fremont. These partnerships have contributed to her research and the successful development of her patented technologies.

Conclusion

Janet Connolly's work exemplifies the intersection of innovation and immunology. Her contributions through her patent on disulfide trap MHC class I molecules highlight her role as a leading inventor in her field.