James T Metz

Title: The Innovations of James T Metz

Introduction

James T Metz is a notable inventor based in Indianapolis, IN (US). He has made significant contributions to the field of chemistry, particularly in the development of nonclassical antifolates. His work has implications for the treatment of diseases that rely on folic acid metabolism.

Latest Patents

One of his key patents is titled "Pyridopyrimidines as nonclassical antifolates." This patent describes 2-Amino-4-hydroxy-4,5,6,7-tetrahydropyrido[2,3-d]pyrimidine derivatives of aromatic amides, such as benzamide or thienylcarboxamide. These compounds serve as inhibitors of enzymes that utilize folic acid, specifically targeting glycinamide ribonucleotide formyl transferase. A typical embodiment of this invention is N-(N-{4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl}-L-γ-glutamyl)-D-aspartic acid. This innovation showcases his expertise in medicinal chemistry and its applications.

Career Highlights

James T Metz is affiliated with Princeton University, where he continues to engage in research and development. His work has led to advancements in the understanding of antifolate mechanisms and their potential therapeutic applications. With a total of 1 patent, he has established himself as a valuable contributor to the scientific community.

Collaborations

Throughout his career, Metz has collaborated with esteemed colleagues, including Chuan Shih and Lynn Stacy Gossett. These partnerships have fostered a collaborative environment that enhances research outcomes and innovation.

Conclusion

James T Metz's contributions to the field of chemistry, particularly through his patent on nonclassical antifolates, highlight his role as an influential inventor. His work continues to impact the scientific community and offers promising avenues for future research.