The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 1998
Filed:
Sep. 04, 1996
Applicant:
Inventors:
Chuan Shih, Carmel, IN (US);
Lynn S Gossett, Indianapolis, IN (US);
William J Gill, Indianapolis, IN (US);
Edward C Taylor, Princeton, NJ (US);
James T Metz, Indianapolis, IN (US);
Assignee:
The Trustees of Princeton University, Princeton, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; A61K / ;
U.S. Cl.
CPC ...
514258 ; 544279 ;
Abstract
2-Amino-4-hydroxy-4,5,6,7-tetrahydropyrido�2,3-d!pyrimidine derivatives of aromatic amides, such as a benzamide or thienylcarboxamide in which the amino portion of the amide is other than L-glutamic acid are inhibitors of enzymes which utilize folic acid, in particular glycinamide ribonucleotide formyl transferase. A typical embodiment is N-(N-{4-�2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido�2,3-d!pyrimidin-6-y l)ethyl!benzoyl}-L-.gamma.-glutamyl)-D-aspartic acid.