James R Seibold

Title: The Innovative Contributions of James R. Seibold

Introduction

James R. Seibold, a distinguished inventor located in Piscataway, NJ, has made significant advancements in the field of immunoassays through his innovative research. With a total of two patents to his name, Seibold's work is pivotal in enhancing the detection of lupus antibodies, a condition that affects many individuals worldwide.

Latest Patents

Seibold's latest patents focus on the development of liposome compositions that are tailored for lupus assays. The first patent involves an immunoassay that utilizes a novel liposome composition, which incorporates both stabilizing or destabilizing components along with an antigen. This innovative approach allows for the detection of cognate antibodies in test samples by observing changes in the supramolecular structure of the liposomes, which leads to significant alterations in stabilization. The presence of magnesium or calcium ions can cause destabilization, while stabilization can be measured via the polymerization of bilayer components in response to ultraviolet light.

The second patent also revolves around a liposome composition for detecting systemic lupus erythematosus (SLE) antibodies. This assay employs a divalent cation responsive indicator that is entrapped within the liposomes. The stabilization of the liposomal structure, induced by these antibodies, is measured, and similar to the first patent, the presence of magnesium or calcium ions can also affect this stabilization.

Career Highlights

James R. Seibold currently works at The Liposome Company, Inc., where he has contributed his expertise in liposomal technologies. His significant patents reflect his dedication to advancing medical diagnostic techniques and his ongoing commitment to research innovation.

Collaborations

Throughout his career, Seibold has collaborated with notable individuals in the field, including Andrew S. Janoff and Marc J. Ostro. These collaborations have further enhanced the depth and impact of his research, leading to innovative solutions in the detection of diseases.

Conclusion

James R. Seibold's contributions to the realm of immunoassays demonstrate his innovative spirit and dedication to scientific advancement. His work with liposome compositions not only advances the field but also provides crucial tools for the detection of lupus antibodies, benefiting both clinicians and patients alike.